[Superoxide anion production and adhesiveness of neutrophils in obese patients]

In 15 subjects with simple obesity and 10 patients with obesity associated with type II diabetes neutrophil adhesiveness and the rate of resting and stimulated production of superoxide anions (O2-) by these cells were assessed. High values were demonstrated of neutrophil adhesiveness suspended in autologous plasma in both groups of patients. The value of O2- production by resting cells was significantly raised, particularly in cases of simple obesity. Stimulated production of superoxides by neutrophils was approaching the value noted in the control group. The obtained results may suggest participation of these cells in the development of atherosclerotic changes.