[Fructose-2,6-diphosphate and glycolysis of tumor cells]

Tumour and proliferative cells maintain a high glycolytic rate even under aerobic conditions. The discovery of fructose-2,6-bisphosphate, a potent stimulator of glycolysis, has prompted a re-investigation of this phenomenon. Rat hepatoma cells and fibroblasts stimulated by mitogens or transformed by the Rous sarcoma virus, were used as models. The results indicate that the stimulation of glycolysis induced by these agents can be explained by an increase in the concentration of fructose-2,6-bisphosphate and in the activity of the enzyme synthesizing it.