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Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo
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Probing SGLT2 as a therapeutic target for diabetes: basic physiology and consequences.

Linda A Gallo1, Ernest M Wright2, Volker Vallon3

  • 1Glycation and Diabetes Complications Research Group, Mater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, QLD, Australia linda.gallo@mater.uq.edu.au.

Diabetes & Vascular Disease Research
|January 25, 2015
PubMed
Summary

Sodium-dependent glucose transporter 2 (SGLT2) inhibitors lower blood glucose by increasing urinary glucose excretion. Dual SGLT1/2 inhibitors are being developed for enhanced diabetes treatment.

Keywords:
Renal glucose reabsorptionanti-diabetic therapycardiovascular outcomeskidney physiology

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