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Related Concept Videos

Humoral Immune Responses01:36

Humoral Immune Responses

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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B Cell Activation and Differentiation01:24

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Special Features of Adaptive Immunity01:20

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The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
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Cells of the Innate Immune Response01:28

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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

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[Plasma cells].

F Hiepe1, T Alexander, R E Voll

  • 1Medizinische Klinik m. S. Rheumatologie und Klinische Immunologie, Deutsches RheumaForschungszentrum Berlin - ein Institut der Leibniz-Gemeinschaft, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland, falk.hiepe@charite.de.

Zeitschrift Fur Rheumatologie
|January 25, 2015
PubMed
Summary
This summary is machine-generated.

Long-lived plasma cells drive chronic autoimmune diseases and are resistant to current therapies. Targeting these specific cells offers a promising strategy for treating refractory conditions.

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Area of Science:

  • Immunology
  • Cell Biology

Context:

  • Plasma cells, terminally differentiated B cells, are crucial for antibody production and humoral immunity.
  • Pathogenic antibodies produced by plasma cells contribute to autoimmune disorders, transplant rejection, and allergies.

Purpose:

  • To highlight the distinct roles of short-lived and long-lived plasma cells in disease pathogenesis.
  • To discuss long-lived memory plasma cells as critical therapeutic targets for refractory autoimmune diseases.

Summary:

  • Two plasma cell populations exist: short-lived cells linked to disease flares and long-lived memory cells responsible for chronic, treatment-resistant conditions.
  • Long-lived plasma cells persist independently of antigen or T/B cell help, making them difficult to target with conventional therapies.
  • Current depletion strategies include immunoablative therapy and proteasome inhibitors, with a focus on antigen-specific elimination of pathogenic plasma cells.

Impact:

  • Identifies long-lived plasma cells as key targets for developing novel treatments for chronic autoimmune and antibody-mediated diseases.
  • Discusses the potential for antigen-specific therapies to selectively eliminate pathogenic plasma cells while preserving protective immunity.