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Updated: Apr 18, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

Microengineered liver tissues for drug testing.

Salman R Khetani¹, Dustin R Berger², Kimberly R Ballinger³

¹Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, USA School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA Salman.Khetani@colostate.edu.

Journal of Laboratory Automation

|January 25, 2015

Summary

This summary is machine-generated.

Engineered human liver models are crucial for preclinical drug development, improving safety and efficacy assessments. These advanced in vitro models offer better prediction of drug-induced liver injury (DILI) and personalized medicine applications.

Keywords:

cocultures drug development drug-induced liver injury hepatocytes microfabrication

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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

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Published on: January 31, 2022

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

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Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

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Published on: June 5, 2020

Area of Science:

Biomedical Engineering
Hepatology
Drug Development

Background:

Drug-induced liver injury (DILI) is a major reason for drug failure in development.
Existing animal models poorly predict human liver responses due to pathway differences.
Human-relevant in vitro liver models are essential for preclinical drug testing.

Purpose of the Study:

To review trends, challenges, and opportunities in engineered human liver models.
To highlight applications and areas for improvement in liver model development.
To discuss the future impact of engineered liver models on drug selection and personalized medicine.

Main Methods:

Development of engineered liver models using primary cells, cell lines, and stem cell-derived hepatocytes.
Leveraging engineering tools for precise microenvironment control and miniaturization.
Integration of liver models into organs-on-a-chip systems for inter-tissue crosstalk.

Main Results:

Engineered liver models offer improved assessment of drug metabolism, toxicity, and efficacy.
High-throughput drug screening is facilitated by miniaturized and controlled microenvironments.
Organs-on-a-chip integration enables systems-level understanding of drug effects.

Conclusions:

Engineered liver models are advancing preclinical drug development by providing human-relevant data.
These models enhance the selection of efficacious and safer drugs.
Future applications include personalized medicine approaches for specific patient populations.