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Updated: Apr 18, 2026

In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression
Published on: March 29, 2019
Long-range gene regulation and novel therapeutic applications
Anita van den Heuvel1, Ralph Stadhouders1, Charlotte Andrieu-Soler2
1Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands;
Abstract:
An intimate relationship exists between nuclear architecture and gene activity. Unraveling the fine-scale three-dimensional structure of the genome and its impact on gene regulation is a major goal of current epigenetic research, one with direct implications for understanding the molecular mechanisms underlying human phenotypic variation and disease susceptibility. In this context, the novel revolutionary genome editing technologies and emerging new ways to manipulate genome folding offer new promises for the treatment of human disorders.
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