Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Atypical Tetracyclines Promote Longevity and Ferroptotic Neuroprotection via Translation Attenuation.

Aging cell·2026
Same author

Atypical tetracyclines promote longevity and ferroptotic neuroprotection via translation attenuation.

bioRxiv : the preprint server for biology·2026
Same author

Nucleosome stability safeguards cell identity, stress resilience and healthy aging.

Research square·2025
Same author

PIEZO channels link mechanical forces to uterine contractions in parturition.

Science (New York, N.Y.)·2025
Same author

Nucleosome stability safeguards cell identity, stress resilience and healthy aging.

bioRxiv : the preprint server for biology·2025
Same author

Autophagy activator AA-20 improves proteostasis and extends <i>Caenorhabditis elegans</i> lifespan.

Proceedings of the National Academy of Sciences of the United States of America·2025

Related Experiment Video

Updated: Apr 18, 2026

A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans
08:49

A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans

Published on: March 20, 2018

9.6K

High-throughput small-molecule screening in Caenorhabditis elegans.

Sunitha Rangaraju1, Gregory M Solis, Michael Petrascheck

  • 1Department of Chemical Physiology, The Scripps Research Institute, 10550 N Torrey Pines Rd, Mail drop: MEM 268, La Jolla, CA, 92037, USA.

Methods in Molecular Biology (Clifton, N.J.)
|January 26, 2015
PubMed
Summary

This study presents a method for large-scale screening of chemical compounds that alter biological functions in the roundworm Caenorhabditis elegans. This approach enables the discovery of novel probes for studying gene and protein activity.

More Related Videos

High-throughput Screening and Biosensing with Fluorescent C. elegans Strains
14:53

High-throughput Screening and Biosensing with Fluorescent C. elegans Strains

Published on: May 19, 2011

18.6K
High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health
11:40

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

Published on: April 28, 2022

3.5K

Related Experiment Videos

Last Updated: Apr 18, 2026

A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans
08:49

A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans

Published on: March 20, 2018

9.6K
High-throughput Screening and Biosensing with Fluorescent C. elegans Strains
14:53

High-throughput Screening and Biosensing with Fluorescent C. elegans Strains

Published on: May 19, 2011

18.6K
High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health
11:40

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

Published on: April 28, 2022

3.5K

Area of Science:

  • Biochemistry
  • Genetics
  • Pharmacology

Background:

  • Chemical compounds are essential tools for investigating biological processes.
  • Modulating enzymatic activities and protein action provides temporal control over biological phenomena.

Purpose of the Study:

  • To describe a methodology for high-throughput screening of chemical compounds.
  • To identify compounds that induce specific phenotypes in Caenorhabditis elegans.

Main Methods:

  • Utilizing 96- or 384-well microtiter plate formats for screening.
  • Employing the model organism Caenorhabditis elegans for phenotypic analysis.

Main Results:

  • A scalable methodology for chemical compound screening was established.
  • The method facilitates the identification of compounds with specific biological effects.

Conclusions:

  • The described methodology offers a robust platform for discovering novel chemical probes.
  • This approach aids in the study of biological phenomena through controlled modulation of enzymatic and protein activities.