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Left Ventricular Systolic Dysfunction in Asymptomatic Black Hypertensive Subjects

Dike Ojji1, John Atherton2, Karen Sliwa3

  • 1Cardiology Unit, Department of Medicine, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria; dikeojjki@yahoo.co.uk.

American Journal of Hypertension
|January 26, 2015
PubMed

Insights

In hypertensive Black Africans without heart failure, 6.7% had asymptomatic left ventricular (LV) systolic dysfunction. This condition was more prevalent in men and those with diabetes mellitus, indicating a need for targeted screening.

Area of Science:

  • Cardiology
  • Hypertension Research
  • African Health Studies

Background:

  • Hypertension is a leading cause of heart failure in sub-Saharan Africa.
  • Previous studies noted high rates of left ventricular (LV) systolic dysfunction in Nigerian hypertensive heart failure patients.
  • Ischemic heart disease is less prevalent in this population.

Purpose of the Study:

  • To determine the prevalence of asymptomatic LV systolic dysfunction.
  • To investigate associated risk factors in hypertensive Black Africans without prior heart failure history.

Main Methods:

  • Clinical and echocardiographic evaluations were performed.
  • 1,947 hypertensive subjects without heart failure were recruited.
  • Data was collected from April 2006 to August 2013 at the University of Abuja Teaching Hospital, Nigeria.

Main Results:

  • 6.7% of subjects exhibited LV systolic dysfunction.
  • Male gender and diabetes mellitus were associated with worse LV systolic function.
  • Factors linked to lower LV ejection fraction (LVEF) included older age, male sex, diabetes, higher LV mass, and specific echocardiographic measurements.

Conclusions:

  • Asymptomatic LV systolic dysfunction affects 6.7% of Black hypertensive individuals.
  • Male gender, diabetes mellitus, and increased LV mass are significant associated factors.
  • These findings highlight the importance of early detection and management in at-risk populations.
Abstract

Keywords:
blood pressurehypertensionleft ventricularsystolic dysfunction.

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