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Related Experiment Video

Updated: Apr 18, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

Tracking nutrient transfer at the human maternofetal interface from 4 weeks to term.

C J P Jones¹, R H Choudhury¹, J D Aplin¹

¹Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester Academic Health Science Centre, St Mary's Hospital, Oxford Road, Manchester M13 9WL, UK.

|January 26, 2015

Summary

This summary is machine-generated.

Decidual glycogen is broken down for placental nutrient uptake. Placental glycosylation and nutrient transfer change significantly during gestation, shifting from histiotrophy to haemotrophy.

Keywords:

Decidua Glycogen Glycoprotein Immunohistochemistry Lectin Placenta

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Published on: June 18, 2013

Area of Science:

Reproductive Biology
Developmental Biology
Cell Biology

Background:

Investigates nutrient transport mechanisms in early and late placental development.
Focuses on glycogen and glycoprotein dynamics in trophoblast cells.

Purpose of the Study:

To track glycogen and glycoprotein flux during nutrient uptake into the placenta.
To understand the transition from histiotrophic to haemotrophic nutrition.

Main Methods:

Immunohistochemical localization of enzymes (α-amylase, glycogen synthase, glycogen phosphorylase).
Lectins staining of placental tissues from 4-18 weeks gestation and term.
Analysis of placental tissues from early (deciduochorial) and late (haemochorial) pregnancy.

Main Results:

Glycogenolysis observed in decidual gland epithelium and placental cells; α-amylase present in decidual secretions but not placenta.
Glycogen and glycogen synthase found in villous cytotrophoblast; significant changes in placental glycosylation during gestation.
Syncytiotrophoblast glycosylation decreases by term, with increased glycosylation in cytotrophoblast.

Conclusions:

Decidual glycogen is utilized for placental metabolism and reassembly.
Trophoblast internalizes and processes histiotrophe, a process declining after haemotrophic nutrition begins.
The shift to haemotrophic nutrition involves reduced uptake of uterine secretory derivatives and glycoproteins, favoring low molecular weight nutrients.