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Related Concept Videos

Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

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A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
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Role of Myosin in Cell Migration01:18

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Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
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Cell Migration01:09

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Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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Cell Migration01:19

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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The Movement of Organelles and Vesicles01:43

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In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
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Microtubules in Cell Motility01:24

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Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
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Related Experiment Video

Updated: Apr 18, 2026

Motility of Single Molecules and Clusters of Bi-Directional Kinesin-5 Cin8 Purified from S. cerevisiae Cells
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Kinesins in cell migration.

Alice Bachmann1, Anne Straube1

  • 1*Centre for Mechanochemical Cell Biology, Warwick Medical School, University of Warwick, Gibbet Hill, Coventry, CV4 7AL, U.K.

Biochemical Society Transactions
|January 27, 2015
PubMed
Summary

Human cells use kinesins, microtubule motors, for transport and cell migration. This review details kinesin roles in cell movement, covering their functions as transporters and track modulators.

Area of Science:

  • Cell Biology
  • Molecular Motors

Background:

  • Human cells possess 45 kinesins, crucial microtubule motor proteins.
  • Kinesins are involved in intracellular transport of molecules and organelles.
  • They also regulate microtubule dynamics, including assembly and disassembly.

Purpose of the Study:

  • To review the known functions of kinesins in cellular migration.
  • To highlight kinesins' dual roles as transporters and microtubule track modulators.

Main Methods:

  • Literature review of scientific articles on kinesin function.
  • Synthesis of current knowledge on kinesin involvement in cell migration.

Main Results:

  • Kinesins transport cargo within cells.

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Related Experiment Videos

Last Updated: Apr 18, 2026

Motility of Single Molecules and Clusters of Bi-Directional Kinesin-5 Cin8 Purified from S. cerevisiae Cells
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  • Kinesins influence cell migration by regulating microtubule-based asymmetry.
  • They modulate cell migration through force generation and substrate adhesion processes.

    • Conclusions:

    • Kinesins are essential for cell migration.
    • Understanding kinesin functions provides insights into cell motility mechanisms.