Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.2K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.8K
1.8K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

5.1K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.8K
1.8K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

5.0K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
5.0K
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

1.5K
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Wide Spectrum of Oncocytic Changes and Tumors in the Kidney: Splitting and Lumping.

Pathobiology : journal of immunopathology, molecular and cellular biology·2021
Same author

Molecular pathology of urothelial carcinoma.

Human pathology·2021
Same author

Digital diagnostics and artificial intelligence in prostate cancer treatment in 5 years from now.

Translational andrology and urology·2021
Same author

Towards a new WHO classification of renal cell tumor: what the clinician needs to know-a narrative review.

Translational andrology and urology·2021
Same author

Narrative review: update on immunotherapy and pathological features in patients with bladder cancer.

Translational andrology and urology·2021
Same author

Narrative review of prostate cancer grading systems: will the Gleason scores be replaced by the Grade Groups?

Translational andrology and urology·2021

Related Experiment Video

Updated: Apr 18, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

14.5K

Oncotargets in different renal cancer subtypes.

Holger Moch, Rodolfo Montironi, Antonio Lopez-Beltran

  • 1Institute of Surgical Pathology, University of Zurich, Zurich, Switzerland. holger.moch@usz.ch.

Current Drug Targets
|January 27, 2015
PubMed
Summary

Clear cell renal cell carcinoma (ccRCC) is genetically diverse, with VHL gene alterations common. Understanding these genetic changes and other tumor suppressor genes aids in developing targeted therapies for renal cancer.

More Related Videos

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
12:22

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

34.3K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

8.1K

Related Experiment Videos

Last Updated: Apr 18, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

14.5K
The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
12:22

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

34.3K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

8.1K

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Renal cell cancer (RCC) is a heterogeneous disease with clear cell RCC (ccRCC) being the most common subtype in adults.
  • ccRCC is characterized by von Hippel-Lindau (VHL) gene alterations, leading to increased vascular endothelial growth factor (VEGF) production.
  • Recent research has uncovered significant genetic heterogeneity within ccRCC, identifying additional tumor suppressor genes on chromosome 3p.

Purpose of the Study:

  • To review the genetic landscape of renal cell carcinoma, focusing on ccRCC.
  • To explore the role of various genetic alterations in renal tumor carcinogenesis, prognosis, and targeted therapy.
  • To correlate morphologic features with molecular genetics for improved targeted therapy strategies.

Main Methods:

  • Review of current literature on renal cell carcinoma genetics and targeted therapies.
  • Analysis of genetic alterations including VHL, PI3K-mTORC1 pathway, and other tumor suppressor genes (FLCN, TSC1/2, TFE3/B, MITF, FH, SDHB/D, MET, PTEN).
  • Examination of the association between morphologic features and molecular genetics in renal cancer.

Main Results:

  • VHL gene inactivation is a key event in ccRCC, driving VEGF production and promoting angiogenesis.
  • The PI3K-mTORC1 signaling axis is a therapeutic target, with mTOR inhibitors showing promise.
  • Multiple genetic alterations in hereditary cancer syndromes contribute to renal tumor development and influence prognosis.

Conclusions:

  • Targeted therapies, including VEGF inhibitors and mTOR inhibitors, are advancing the treatment of metastatic ccRCC.
  • Understanding the molecular basis of renal cancer, including genetic heterogeneity and specific gene alterations, is crucial for developing effective, personalized treatment strategies.
  • Integrating morphologic and molecular data provides a foundation for precision medicine in renal cancer therapy.