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Updated: Apr 18, 2026

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
T cell tuning for tumour therapy: Enhancing effector function and memory potential of therapeutic T cells
Mathias H Zech, Pedro Velica, Hans J Stauss1
1Institute of Immunity & Transplantation, Division of Infection & Immunity, University College London, Royal Free Hospital, Rowland Hill Street, London NW3 2PF, United Kingdom. h.stauss@ucl.ac.uk.
Abstract:
The genetic engineering of T cells can lead to enhanced immune-mediated tumour destruction and harbors a great potential for the treatment of cancer. Recent efforts have centered on the design of receptors to re-direct the specificity of T cells towards tumour antigens by means of viral gene transfer. This strategy has shown great success in a number of phase one clinical trials. However, there are still challenges to overcome. On the one hand, T cell function can be further improved to optimize the therapeutic outcome. On the other hand, so called safety switches are required to deal with possible on and off target toxicities. In this review, we will give a brief summary of the success and risks of T cell gene therapy before discussing in detail current strategies to enhance effector function, persistence and safety of adoptively transferred T cells.
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