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Targeting post-ejaculation sperm for value-added contraception.

Gopal Gupta, Santosh Jangir, Vishnu L Sharma1

  • 1CSIR-Central Drug Research Institute, Lucknow 226031, India. g_gupta@cdri.res.in.

Current Molecular Pharmacology
|January 27, 2015
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Summary
This summary is machine-generated.

Chemical contraception targets sperm in the vagina, offering a reversible, on-demand method. Research focuses on designed chemical synthesis to inhibit sperm and prevent infections.

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Area of Science:

  • Reproductive biology
  • Pharmacology
  • Contraception

Background:

  • Spermatogenesis, the process of sperm production, occurs in the testes and is regulated by hormones and temperature.
  • Epididymal maturation is crucial for sperm motility and fertilizing ability, making it a target for male contraceptive research.
  • Current male contraceptive methods are limited, with no clinically viable options available yet.

Purpose of the Study:

  • To review recent advancements in chemical contraception targeting vaginal spermatozoa.
  • To explore the use of designed chemical synthesis for developing novel contraceptive agents.
  • To investigate methods for inhibiting sperm and preventing sexually transmitted infections.

Main Methods:

  • Review of recent research endeavors in chemical contraception.
  • Application of designed chemical synthesis approaches.
  • Focus on inhibiting sperm function and preventing infections in the vaginal environment.

Main Results:

  • Epididymal sperm gain motility and fertilizing capacity during transit.
  • Vaginal spermatozoa are a long-standing target for contraceptive strategies.
  • Chemical agents can inactivate sperm 'ex-vivo' in the vagina, offering potential contraceptive benefits.

Conclusions:

  • Chemical contraception utilizing vaginal sperm inactivation is a promising area.
  • Designed chemical synthesis offers a novel approach to developing effective and safe contraceptives.
  • Targeting vaginal spermatozoa provides a reversible, on-demand, and potentially infection-obliterating contraceptive method.