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Stem cells for the treatment of musculoskeletal pain

Luminita Labusca1, Florin Zugun-Eloae1, Kaveh Mashayekhi1

  • 1Luminita Labusca, Department of Orthopedic Surgery, University Hospital Saint Spiridon, 700111 Iasi, Romania.

World Journal of Stem Cells
|January 27, 2015
PubMed

Insights

Musculoskeletal pain affects over a third of adults globally and is often undertreated. Stem cell therapies, including mesenchymal stem cells, show promise for managing this widespread condition.

Area of Science:

  • Regenerative Medicine
  • Pain Management
  • Biomarkers

Background:

  • Musculoskeletal pain is a leading cause of disability worldwide, affecting over 33% of adults.
  • Current understanding of pain mechanisms in musculoskeletal diseases is incomplete, leading to underdiagnosis and undertreatment.
  • Objective molecular biomarkers are needed for evaluating pain and treatment efficacy.

Purpose of the Study:

  • To review current stem cell-based therapies for musculoskeletal pain.
  • To explore novel perspectives in regenerative medicine for pain treatment.
  • To highlight the need for targeted therapeutic approaches.

Main Methods:

  • Review of existing literature on stem cell therapies for musculoskeletal pain.
  • Analysis of clinical trials involving mesenchymal stem cells for pain endpoints.
  • Discussion of genetically engineered and induced pluripotent stem cells in pain management.

Main Results:

  • Stem cell therapy, particularly using mesenchymal stem cells, is under active investigation for musculoskeletal pain.
  • Various clinical trials are evaluating stem cell therapies with pain as a primary or secondary outcome.
  • Genetically engineered and induced pluripotent stem cells represent emerging therapeutic avenues.

Conclusions:

  • Stem cell-based regenerative medicine offers promising strategies for treating musculoskeletal pain.
  • Further research and a focused therapeutic approach are crucial for clinical acceptance and efficacy.
  • Development of molecular biomarkers will aid in objective evaluation and personalized treatment of pain.
Keywords:
Molecular biomarkersMusculoskeletal painStem cells

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