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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Author Spotlight: Long-Term Spinal Cord Slice Culture for Advancing Spinal Cord Regeneration Therapies
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Stem cells for spine surgery.

Joshua Schroeder1, Janina Kueper1, Kaplan Leon1

  • 1Joshua Schroeder, Kaplan Leon, Meir Liebergall, Department of Orthopedic Surgery, Spine Surgery, Hadassah Medical Center, Kiryat Hadassah, Jerusalem 91120, Israel.

World Journal of Stem Cells
|January 27, 2015
PubMed
Summary
This summary is machine-generated.

Adult stem cell therapy shows promise for treating various diseases and injuries, including spinal conditions. While research is ongoing, its translation to clinical practice for conditions like neural damage and disk degeneration is advancing.

Keywords:
FusionIntervertebral disk regenerationPeripheral nerve damageSkeletal muscle regenerationSpinal cord injurySpine surgeryStem cell

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Area of Science:

  • Regenerative Medicine
  • Tissue Engineering
  • Stem Cell Biology

Background:

  • Adult stem cells from bone marrow, adipose tissue, or blood are explored for therapeutic applications.
  • Embryonic stem cells face utilization limitations due to ethical concerns.
  • Stem cell transplantation is studied for treating diverse conditions like myocardial infarction and Alzheimer's disease.

Purpose of the Study:

  • To review the current state of stem cell therapy in regenerative medicine.
  • To highlight the potential applications of stem cells in spinal surgery.
  • To discuss the challenges and progress in translating stem cell research from the lab to the clinic.

Main Methods:

  • Review of existing literature on stem cell transplantation.
  • Analysis of animal models and clinical trials investigating stem cell efficacy.
  • Examination of stem cell potential in treating neural damage, muscle trauma, disk degeneration, and bone fusion.

Main Results:

  • Adult stem cells have been experimentally used to treat a wide range of diseases.
  • Studies in animal models and clinical trials show the physiological impact of stem cell transplantation on functional recovery.
  • Stem cell therapy is gaining attention in spinal surgery for its potential benefits.

Conclusions:

  • Stem cell therapy holds significant potential for treating spinal conditions such as neural damage, muscle trauma, and disk degeneration.
  • Despite slow translation to clinical practice, ongoing research continues to explore the therapeutic benefits of adult stem cells.
  • Further investigation is needed to fully realize the potential of stem cell therapy in regenerative medicine and spinal surgery.