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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
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Dissipative particle dynamics study on self-assembled platycodin structures: the potential biocarriers for drug
Xingxing Dai1, Haiou Ding2, Qianqian Yin3
1Beijing University of Chinese Medicine, Beijing 100102, China; Key Laboratory of TCM-information Engineer of State Administration of TCM, Beijing 100102, China.
Journal of Molecular Graphics & Modelling
|January 27, 2015
Summary
Platycodin, plant-based biosurfactants, form diverse micelle structures in water. Dissipative particle dynamics simulations reveal factors influencing their self-assembly for drug delivery applications.
Area of Science:
- Biochemistry
- Materials Science
- Computational Chemistry
Background:
- Platycodin, saponins from Platycodon grandiflorum, are plant-based biosurfactants.
- They exhibit potential for enhancing hydrophobic drug solubility and acting as drug carriers via micellization above critical micelle concentration (CMC).
Purpose of the Study:
- To investigate factors influencing platycodin micellization behavior.
- To detail the phase behavior of platycodin at a mesoscopic level.
Main Methods:
- Dissipative particle dynamics (DPD) simulations were employed.
- Simulations explored aggregate morphology and phase diagrams.
Main Results:
- A variety of aggregate morphologies were observed, including spherical, elliptical, and oblate micelles, vesicles, multilamellar vesicles (MLVs), multicompartment vesicles (MCMs), and tubular/necklace-like micelles.
- These structures formed spontaneously and were mapped in phase diagrams.
- Concentration-dependent structural variations and MLV formation mechanisms were analyzed.
Conclusions:
- The study provides insights into platycodin solubilization systems.
- Findings may guide the pharmaceutical development and application of platycodin and other saponins.
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