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Chronic infectious mononucleosis; a case report.

I Talstad¹, H Scott, P Jenum

¹Medical Department, Haukeland Hospital, University of Bergen, Norway.

Journal of Internal Medicine

|December 1, 1989

Summary

This summary is machine-generated.

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A woman experienced prolonged illness with swollen lymph nodes and enlarged spleen, showing abnormal blood cells and high Epstein-Barr virus antibody levels. Splenectomy led to improvement, suggesting a benign viral cause for her condition.

Area of Science:

Immunology
Virology
Hematology

Background:

Adenitis colli can present with systemic symptoms.
Epstein-Barr virus (EBV) infections can manifest with hematological abnormalities.

Observation:

A 39-year-old woman presented with adenitis colli, anemia, splenomegaly, and atypical lymphoid cells.
Blood analysis revealed increased B-lymphocytes, decreased T-suppressor/cytotoxic cells, and polyclonal IgM.
High antibody titers for EBV VCA IgG, EB EA IgD&R +/-, and EBNA IgG- were detected.

Findings:

The patient's condition progressed slowly over two years.
Splenectomy resulted in significant clinical improvement.
Spleen morphology indicated a benign disease, likely of viral origin.

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Implications:

This case highlights the potential for EBV to cause prolonged, complex hematological presentations.
Splenectomy can be an effective treatment for specific EBV-associated splenomegalies.
Further research into EBV's role in benign lymphoid disorders is warranted.