Related Experiment Video
Updated: Apr 18, 2026

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
Published on: February 9, 2020
[Cellular adhesion signal transduction network of tumor necrosis factor-alpha induced hepatocellular carcinoma cells]
Yongchang Zheng1, Shunda Du1, Haifeng Xu1
1Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Objective:
To systemically explore the cellular adhesion signal transduction network of tumor necrosis factor-alpha (TNF-α)-induced hepatocellular carcinoma cells with bioinformatics tools.
Methods:
Published microarray dataset of TNF-α-induced HepG2, human transcription factor database HTRI and human protein-protein interaction database HPRD were used to construct and analyze the signal transduction network.
Results:
In the signal transduction network, MYC and SP1 were the key nodes of signaling transduction. Several genes from the network were closely related with cellular adhesion.Epidermal growth factor receptor (EGFR) is a possible key gene of effectively regulating cellular adhesion during the induction of TNF-α.
Conclusion:
EGFR is a possible key gene for TNF-α-induced metastasis of hepatocellular carcinoma.
More Related Videos
06:54Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
Published on: October 27, 2020
10:57Examining the Dynamics of Cellular Adhesion and Spreading of Epithelial Cells on Fibronectin During Oxidative Stress
Published on: October 13, 2019
Related Concept Videos
Intracellular Signaling Affects Focal Adhesions
Some...
Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...
Regulation of Angiogenesis and Blood Supply
The Tumor Microenvironment
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...