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Updated: Apr 18, 2026

11:09
Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
Published on: August 1, 2018
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Photocontrolled chignolin-derived β-hairpin peptidomimetics
T Podewin1, M S Rampp, I Turkanovic
1Department of Organic Chemistry, Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-University LMU, 81377 Munich, Germany. anja.hoffmann-roeder@cup.lmu.de.
Abstract:
The synthesis of novel, chignolin-derived peptides comprising the azobenzene photoswitch [3-(3-aminomethyl)phenylazo]phenylacetic acid (AMPP) is reported. Reversible photoswitching behavior led to folding into β-hairpin-like structures, as unequivocally demonstrated by CD, FT-IR and NMR spectroscopy.

