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[Prognostic significance of CXCR2 expression in pancreatic ductal carcinoma]
Qingqing Wang1, Jinyu Zheng, Qichao Ni
1First Affiliated Hospital, Soochow University, Suzhou 215006, China.
Objective:
To explore the relationship between the expression of CXC chemokine receptor 2 (CXCR2) and the clinicopathologic features with prognosis in pancreatic ductal carcinoma (PDAC) tissues.
Methods:
The CXCR2 expression in 161 PDAC tissues were detected with immunohistochemistry using anti-human CXCR2 antibody and tissues microarray.
Results:
The expression of CXCR2 in PDAC tumor tissues was higher than that in normal pancreatic tissues (χ(2) = 11.437, P = 0.001). The comparison of clinicopathologic characteristics and immunohistochemistry by χ(2) test analysis showed that a high expression of CXCR2 in PDAC was correlated with vascular invasion (χ(2) = 6.489, P = 0.011) and late TNM stage (χ(2) = 6.205, P = 0.013). Kaplan-Meier survival and Cox regression analyses showed that a high expression of CXCR2 (HR: 5.514, P = 0.016) was an independent prognostic factor.
Conclusion:
A high expression of CXCR2 denotes a poor prognosis in PDAC.
