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[Opsoclonic cerebellar disease. A paraneoplastic syndrome sensitive to chlormethiazole]

A Lago, J A Burguera, J J Vilchez

    Anales De Medicina Interna (Madrid, Spain : 1984)
    |May 1, 1989
    PubMed

    Insights

    Opsoclonus, a rare eye movement disorder, can be a paraneoplastic symptom. This case highlights opsoclonus preceding breast carcinoma diagnosis, with complete symptom resolution after chlormethiazole treatment.

    Area of Science:

    • Neurology
    • Oncology
    • Ophthalmology

    Background:

    • Opsoclonus is a rare ocular dyskinesia.
    • It is often associated with viral infections or neoplasms, including neuroblastoma in children and carcinoma in adults.

    Observation:

    • This report details a case of opsoclonus presenting as a paraneoplastic symptom.
    • The opsoclonus preceded the diagnosis of breast carcinoma in the patient.

    Findings:

    • The patient's abnormal eye movements (opsoclonus) showed a complete response to chlormethiazole.
    • This suggests a potential therapeutic role for chlormethiazole in managing paraneoplastic opsoclonus.

    Implications:

    • This case underscores the importance of considering paraneoplastic syndromes in the differential diagnosis of opsoclonus.
    • Early recognition and treatment of the underlying malignancy are crucial.
    • Chlormethiazole may offer a treatment option for this rare neurological manifestation.

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