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Published on: September 22, 2023
[Expression of CD55 and CD59 in chronic rhinosinusitis and its significance]
Lei Xia1, Yinfeng Wang1, Wei Gao1
1Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Provincial Hospital of Anhui Medical University, Hefei 230001, China.
Objective:
To understand the expression of complement regulatory proteins CD55 and CD59, which secreted by epithelial cells of normal and chronic sinusitis patients.
Methods:
Cell culture and flow cytometry were used to detect the expression of complement regulatory proteins CD55 and CD59.SPSS 18.0 software was used to analyze the data.
Results:
CD55 was expressed both in normal nasal mucosa and mucosa of chronic sinusitis. The expression in normal group was 0.001 ± 0.001, significantly lower than that in CRS group which was 0.067 ± 0.028 (t = -10.535, P < 0.01). CD59 was also expressed in the two groups . In normal group, the expression of CD59 was 0.879 ± 0.005, significantly higher than that in CRS group which was 0.238 ± 0.034 (t = 83.416, P < 0.01).
Conclusions:
The nasal mucosa in CRS patients showed low expression of CD55 and high expression of CD59. This mechanism may be involved in the occurrence of CRS.
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