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Rheumatoid arthritis. The two faces of Rsk2 in hyperplastic disease

Jane Falconer1, Christopher D Buckley1

  • 1Rheumatology Research Group, Centre for Translational Inflammation Research, School of Immunity &Infection, College of Medical &Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, Birmingham B15 2WD, UK.

Nature Reviews. Rheumatology
|January 28, 2015
PubMed

Insights

90 kDa ribosomal S6 kinases (Rsk) are implicated in cancer, but Rsk2 also inhibits hyperplasia in rheumatoid arthritis. This dual role raises questions about targeting Rsk2 for arthritis treatment.

Area of Science:

  • Molecular biology
  • Oncology
  • Rheumatology

Background:

  • 90 kDa ribosomal S6 kinases (Rsk) play a known role in cancer development.
  • Rsk-blocking agents are being developed as cancer therapies.
  • The specific function of Rsk2 in rheumatoid arthritis (RA) is not well understood.

Purpose of the Study:

  • To investigate the role of Rsk2 in the context of arthritic synovium.
  • To determine if Rsk2's function in RA is consistent with its role in oncogenesis.
  • To evaluate the potential risks of targeting Rsk2 for rheumatoid arthritis treatment.

Main Methods:

  • The study likely involved analyzing synovial tissue from patients with rheumatoid arthritis.
  • Investigating the expression and activity of Rsk2 in these tissues.
  • Potentially using cell-based assays or animal models to study Rsk2 function in hyperplasia.

Main Results:

  • Rsk2 was found to mediate the inhibition of hyperplasia in the arthritic synovium.
  • This suggests a potentially opposing role for Rsk2 in rheumatoid arthritis compared to its role in cancer.
  • The findings highlight a functional duality of Rsk2.

Conclusions:

  • Rsk2 exhibits a dual role, acting in oncogenesis and also inhibiting hyperplasia in rheumatoid arthritis.
  • Targeting Rsk2 for rheumatoid arthritis treatment may carry risks due to its complex functions.
  • Further research is needed to understand the implications of Rsk2's dual role in therapeutic strategies for RA.

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