Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nuclear bodies in the normal and hyperfunctional human adrenal cortex.

M M Magalhães1, D Carvalho, M A Oliveira

  • 1Institute of Histology and Embryology, Faculty of Medicine of Porto, Portugal.

Histology and Histopathology
|April 1, 1989
PubMed
Summary

Nuclear bodies in adrenal cortex cells were observed in both healthy and Cushing's disease patients. Complex nuclear bodies were more prevalent in adrenal pathology, suggesting a link to adrenal function and ACTH stimulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of dietary tannins and compounds from fermentation of Saccharomyces cerevisiae on intake, productive performance, enteric methane emission, and rumen microbial diversity of lactating dairy cows.

Journal of dairy science·2026
Same author

Modeling the eutrophication process in Tucuruí, a tropical amazonian reservoir.

Brazilian journal of biology = Revista brasleira de biologia·2025
Same author

Addressing Critical Fungal Pathogens Under a One Health Perspective: Key Insights from the Portuguese Association of Medical Mycology.

Mycopathologia·2025
Same author

Detection of an Alphacoronavirus in a Brazilian Bat (Molossus sp.).

Journal of molecular evolution·2025
Same author

First records of Zaprionus tuberculatus (Diptera: Drosophilidae) in strawberry in Brazil.

Brazilian journal of biology = Revista brasleira de biologia·2024
Same author

Author Correction: High-resolution surface temperature changes for Portugal under CMIP6 future climate scenarios.

Scientific reports·2024

Area of Science:

  • Endocrinology
  • Cell Biology
  • Pathology

Background:

  • Adrenal cortex cells contain nuclear bodies, structures whose function and significance remain largely uncharacterized.
  • Previous research has not extensively detailed the morphology and prevalence of these nuclear bodies across different adrenocortical states.

Purpose of the Study:

  • To investigate the presence and morphology of nuclear bodies in the adrenal cortex of patients with and without Cushing's disease.
  • To explore the potential relationship between adrenal nuclear bodies and adrenocortical function, particularly in relation to ACTH stimulation.

Main Methods:

  • Microscopic examination of adrenal tissue samples from six female patients (three healthy, three with Cushing's disease).
  • Detailed morphological analysis of simple and complex nuclear bodies within all zones of the adrenal cortex.

Related Experiment Videos

Main Results:

  • Simple and complex nuclear bodies were identified in all adrenal cortex zones across all patients.
  • Complex nuclear bodies exhibited greater numbers and heterogeneity in patients with adrenal pathology (Cushing's disease).
  • Morphological variations included granular, filamentous, or mixed core compositions, vacuolar aspects, and associations with nucleoli or interchromatin granules.

Conclusions:

  • Adrenal nuclear bodies, particularly complex forms, are associated with adrenal pathology.
  • The observed differences suggest a potential role for these nuclear bodies in cellular responses to hormonal stimulation, such as ACTH.