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The clinical utility of pharmacological agents that act at serotonin receptors
S J Peroutka1, A J Sleight, B G McCarthy
1Department of Neurology, Stanford University, CA 94305.
The Journal of Neuropsychiatry and Clinical Neurosciences
|January 1, 1989
Abstract:
The past decade has seen important advances in the clinical utility of serotonergic agents. The putative novel anxiolytic effects of 5-HT1A partial agonists such as buspirone, the antidepressant effects of selective serotonin (5-HT) uptake blockers such as fluoxetine, and the unique and potent antiemetic effects of 5-HT3 antagonists in cancer chemotherapy are excellent examples of the clinical relevance of selective 5-HT receptor agents. The increasing ability to modulate serotonergic neurotransmission through distinct 5-HT receptor subtypes should greatly facilitate the analysis of 5-HT in both normal and abnormal human brain function.