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Neisseria meningitidis ST-11 clonal complex, Chile 2012

Pamela Araya, Jorge Fernández, Felipe Del Canto

    Emerging Infectious Diseases
    |January 28, 2015
    PubMed

    Insights

    Invasive meningococcal disease in Chile was primarily caused by Serogroup W Neisseria meningitidis in 2012. A hypervirulent strain, W:P1.5,2:ST-11, with a specific fHbp gene allele, was identified, leading to increased fatalities.

    Area of Science:

    • Microbiology
    • Epidemiology
    • Genetics

    Background:

    • Neisseria meningitidis is a significant cause of bacterial meningitis.
    • Serogroup W strains have emerged as a public health concern globally.

    Observation:

    • In 2012, Serogroup W Neisseria meningitidis predominated invasive meningococcal disease cases in Chile.
    • A higher case-fatality rate was observed compared to previous years.

    Findings:

    • Genotyping identified a hypervirulent lineage, W:P1.5,2:ST-11.
    • This lineage harbored allele 22 of the fHbp gene.

    Implications:

    • Understanding the genetic characteristics of dominant strains is crucial for disease control.
    • The identified hypervirulent strain may necessitate updated vaccination or treatment strategies.

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