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Angiotensin II, oxidative stress and stem cell therapy: a matter of delicacy

Anton J M Roks1

  • 1*Department of Internal Medicine, Division of Vascular Medicine and Pharmacology, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.

Clinical Science (London, England : 1979)
|January 29, 2015
PubMed

Insights

Stem cell therapy success hinges on donor health. Excessive angiotensin II and reactive oxygen species (ROS) in donors impair stem cell performance, impacting regenerative medicine after kidney injury.

Area of Science:

  • Regenerative Medicine
  • Cardiovascular Physiology
  • Renal Pathophysiology

Background:

  • Stem cell therapy efficacy is influenced by donor health.
  • The renin-angiotensin system (RAS) is crucial for cardiovascular and renal homeostasis.
  • RAS activity impacts stem cell therapeutic potential.

Purpose of the Study:

  • To investigate the effects of excessive angiotensin II signaling and ROS formation in stem cell donors.
  • To explore the consequences for regenerative medicine applications, particularly after renal injury.

Main Methods:

  • Utilized a preclinical model of regenerative medicine.
  • Focused on a model of renal injury in the context of stem cell donation.
  • Examined the role of angiotensin II and reactive oxygen species (ROS) in the donor.

Main Results:

  • Excessive angiotensin II signaling in the stem cell donor negatively affects therapeutic outcomes.
  • Increased reactive oxygen species (ROS) formation in the donor compromises stem cell function.
  • Donor-derived RAS overactivation poses a challenge for stem cell therapy post-renal injury.

Conclusions:

  • Stem cell donor health, specifically RAS status and oxidative stress levels, is critical for successful stem cell therapy.
  • Strategies to modulate donor RAS activity and reduce ROS may enhance stem cell therapy effectiveness.
  • Further research is needed to optimize donor selection and preparation for regenerative medicine.

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