Related Experiment Video
Updated: Apr 18, 2026
13:21
Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
15.5K
Adverse allergic reactions to linear ionic gadolinium-based contrast agents: experience with 194, 400 injections
S Aran1, K W Shaqdan1, H H Abujudeh1
1Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Founders Building, Room 210, Boston, MA 02114, USA.
Clinical Radiology
|January 29, 2015
Summary
Adverse reactions to gadolinium-based contrast agents (GBCAs) occurred in 0.1% of patients. Gadofosveset trisodium showed the highest reaction rate (0.80%), while gadopentetate dimeglumine had the lowest (0.09%).
Area of Science:
- Radiology
- Pharmacovigilance
- Medical Imaging
Background:
- Gadolinium-based contrast agents (GBCAs) are widely used in medical imaging.
- Understanding the incidence and risk factors of adverse reactions is crucial for patient safety.
- This study evaluates four specific GBCAs in a large patient cohort.
Purpose of the Study:
- To assess the incidence of adverse reactions associated with four different GBCAs.
- To identify potential risk factors influencing GBCA-related adverse events.
- To compare the safety profiles of gadopentetate dimeglumine, gadofosveset trisodium, gadoxetate disodium, and gadobenate dimeglumine.
Main Methods:
- Retrospective analysis of 194,400 GBCA administrations from 2007-2014.
- Data sourced from an electronic incident reporting system at a single academic medical center.
- Adverse reactions were categorized by severity, patient type, and examination type.
Main Results:
- An overall adverse reaction rate of 0.1% (204/194,400) was observed.
- Gadofosveset trisodium had the highest reaction rate (0.80%), followed by gadoxetate disodium (0.31%), gadobenate dimeglumine (0.22%), and gadopentetate dimeglumine (0.09%).
- Significant differences in reaction rates were found between various GBCAs, with higher rates in females and outpatients.
Conclusions:
- The overall incidence of adverse reactions to the studied GBCAs is low (0.1%).
- Significant variations in adverse reaction rates exist among different GBCAs.
- Gadofosveset trisodium demonstrated a higher incidence of adverse reactions compared to other agents evaluated.
Related Concept Videos
01:14Imaging Studies I: CT and MRI
1.3K
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
1.3K
01:30Radiological Investigation I: X-ray and CT
1.7K
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
1.7K
01:27Imaging Studies III: Computed Tomography
816
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
816
01:12Local Anesthetics: Adverse Effects
1.0K
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
1.0K
01:30Drug Toxicity: Allergic Reactions
181
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
181
01:28Imaging Studies for Cardiovascular System V: CT
631
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
631