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Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp

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Published on: June 20, 2018

MDAT- Aligning multiple domain arrangements.

Carsten Kemena¹, Tristan Bitard-Feildel², Erich Bornberg-Bauer³

¹Institute for Evolution and Biodiversity, University of Münster, Hüfferstr. 1, Münster, Germany. c.kemena@uni-muenster.de.

BMC Bioinformatics

|January 29, 2015

Summary

This summary is machine-generated.

We developed MDAT, a new tool for multiple domain alignments. This program aids in analyzing evolutionary changes in protein domain arrangements, offering insights into protein evolution.

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Area of Science:

Biochemistry
Bioinformatics
Evolutionary Biology

Background:

Proteins are functional units composed of independently folding domains.
Domain arrangements in proteins change over evolutionary time through gain, loss, or rearrangement.
Analyzing these evolutionary changes requires effective alignment methods.

Purpose of the Study:

To develop a computational tool for aligning multiple domain arrangements.
To extend existing pairwise alignment methods to handle multiple domain arrangements.

Main Methods:

Developed MDAT, a novel alignment program for multiple domain arrangements.
Utilized a domain similarity matrix for scoring domain pairs.
Employed a consistency-supported progressive alignment method for domain arrangement alignment.

Main Results:

MDAT successfully aligns multiple domain arrangements, extending pairwise alignment capabilities.
The program facilitates the analysis of domain arrangement changes within and between protein families.

Conclusions:

MDAT provides valuable insights into protein and domain evolution.
The MDAT software is freely available for academic use.