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Updated: Apr 18, 2026
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Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
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Acute liver failure and self-medication.
André Vitorio Câmara de Oliveira1, Frederico Theobaldo Ramos Rocha1, Sílvio Romero de Oliveira Abreu1
1Centro Universitário Cesmac, Maceió, AL, Brazil.
Summary
Unsafe self-medication, particularly with acetaminophen and herbal supplements, poses a significant risk for acute liver failure. Public awareness and stricter regulations are crucial to prevent drug-induced liver injury.
Area of Science:
- Pharmacology
- Hepatology
- Public Health
Background:
- Irresponsible self-medication, often involving high drug doses and alcohol, can lead to severe liver damage and failure.
- Drug interactions and overdose are significant risks associated with unsupervised medication use.
Purpose of the Study:
- To highlight the causal link between self-medication practices and the incidence of acute liver failure.
- To raise awareness about the dangers of over-the-counter medications and supplements when misused.
Main Methods:
- A comprehensive literature search was conducted using databases like PubMed, Cochrane Library, SciELO, and Lilacs.
- Keywords included "acute liver failure," "acetaminophen," "self-medication," "dietary supplements," and "green tea."
- Twenty-seven articles and five relevant websites were selected for this review.
Main Results:
- Acetaminophen and certain herbal medicines, especially those for weight loss, are frequently implicated in drug-induced liver failure.
- Inadequate legislation, poor supervision, and limited public information contribute to the prevalence of these cases.
Conclusions:
- Health authorities must enhance regulatory oversight and public education regarding potentially harmful medications.
- Stricter controls on the sale of certain drugs, including requiring prescriptions, are recommended to mitigate risks.
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