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Thyroid nodules and thyroid cancer in Graves' disease
Abbas Ali Tam1, Cafer Kaya1, Fevzi Balkan Mehmet Kılıç1
1Department of Endocrinology and Metabolism, Ataturk Training and Research Hospital, Ankara, Turkey.
Arquivos Brasileiros De Endocrinologia E Metabologia
|January 29, 2015
Summary
Thyroid nodules are common in Graves' disease patients undergoing surgery. The presence of a nodule significantly increases the risk of thyroid cancer in these individuals, necessitating careful evaluation.
Area of Science:
- Endocrinology
- Oncology
- Thyroidology
Background:
- The association between Graves' disease and thyroid nodules is debated.
- The risk of thyroid cancer in Graves' disease patients with nodules requires further clarification.
Purpose of the Study:
- To determine the frequency of thyroid nodules in Graves' disease patients.
- To assess the risk of thyroid cancer in Graves' disease patients with co-occurring nodules.
Main Methods:
- Retrospective analysis of 526 patients who underwent thyroidectomy for Graves' disease (2006-2013).
- Exclusion criteria included prior radioactive iodine treatment, neck irradiation, or previous thyroid surgery.
Main Results:
- Thyroid nodules were found in 33.6% of Graves' disease patients.
- The incidence of thyroid cancer was 8% overall, with a significantly higher rate (13%) in patients with nodules compared to those without (5.4%).
- The presence of a nodule was a significant risk factor for thyroid cancer (p = 0.003).
Conclusions:
- Graves' disease patients, particularly those under surveillance, require thorough evaluation for concomitant thyroid nodules.
- Careful follow-up is essential to detect thyroid cancer in Graves' disease patients with nodules.
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