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Subfoveal choroidal thickness changes after intravitreal ranibizumab and photodynamic therapy for retinal angiomatous
Ichiro Maruko1, Tomohiro Iida, Hiroshi Oyamada
1*Department of Ophthalmology, School of Medicine, Fukushima Medical University, Fukushima, Japan; and †Department of Ophthalmology, School of Medicine, Tokyo Women's Medical University, Tokyo, Japan.
Purpose:
To evaluate the subfoveal choroidal thickness changes after intravitreal ranibizumab and photodynamic therapy in patients with retinal angiomatous proliferation.
Methods:
Subfoveal choroidal thickness was retrospectively measured using enhanced depth imaging optical coherence tomography.
Results:
Thirty-two eyes of 26 patients (average age, 82 years) with newly diagnosed retinal angiomatous proliferation were examined. All eyes were treated with intravitreal ranibizumab and photodynamic therapy. In 14 eyes without recurrence over 6-month follow-up (average, 8.4 months), mean subfoveal choroidal thickness decreased from 198 μm at baseline to 169 μm (85.4%) at 3 months and to 173 μm (87.3%) at 6 months after treatment (P < 0.01 compared with baseline, respectively). In 18 eyes with recurrence over 3-month follow-up, mean subfoveal choroidal thickness decreased from 199 μm at baseline to 171 μm (85.9%) at 3 months after treatment and 176 μm (88.4%) even at recurrence (P < 0.01 compared with baseline, respectively).
Conclusion:
Subfoveal choroidal thickness after intravitreal ranibizumab and photodynamic therapy for retinal angiomatous proliferation decreased to approximately 85% compared with baseline by 3 months after treatment, and the trend persisted in eyes with or without recurrence during follow-up. This may indicate that choroidal changes are not associated with recurrence in retinal angiomatous proliferation.
