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Relationship between LSD1 expression and E-cadherin expression in prostate cancer.

Min Wang1, Xiuheng Liu, Guanjun Jiang

  • 1Department of Urology, Renmin Hospital of Wuhan University, Wuhan University, Jiefang Road 238, Wuhan, 430060, Hubei, People's Republic of China, drwangmin@163.com.

International Urology and Nephrology
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Summary

High lysine-specific demethylase 1 (LSD1) expression and low E-cadherin expression predict prostate cancer progression and metastasis. Inhibiting LSD1 may offer a new therapeutic strategy for prostate cancer prevention.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Prostate cancer progression is complex, involving molecular changes.
  • Lysine-specific demethylase 1 (LSD1) and E-cadherin are implicated in cancer development.

Purpose of the Study:

  • To investigate the relationship between LSD1 and E-cadherin expression in prostate cancer.
  • To determine the prognostic significance of LSD1 and E-cadherin in prostate cancer.

Main Methods:

  • Immunohistochemistry was used to detect LSD1 and E-cadherin expression in prostate cancer tissues.
  • Correlation analysis assessed the relationship between LSD1 and E-cadherin.
  • LNCap cells were treated with Pargyline (LSD1 inhibitor) and analyzed via Western blot.

Main Results:

  • LSD1 expression was elevated, while E-cadherin expression was reduced in prostate cancer compared to benign tissues.
  • LSD1 expression correlated positively with Gleason Score, metastasis, and poor prognosis.
  • E-cadherin expression correlated negatively with Gleason Score and metastasis.
  • LSD1 expression was negatively correlated with E-cadherin expression (rs = -0.486, P = 0.001).
  • High LSD1 and low E-cadherin predicted increased progression and decreased survival.
  • Pargyline inhibited LSD1 activity and increased E-cadherin expression.

Conclusions:

  • Combined high LSD1 and low E-cadherin expression may predict prostate cancer progression and metastasis.
  • Inhibition of LSD1 presents a potential therapeutic target for prostate cancer prevention.