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The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
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The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

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Decreased ARID1A expression correlates with poor prognosis of clear cell renal cell carcinoma

Jeong Hwan Park1, Cheol Lee1, Ja Hee Suh1

  • 1Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea, 110-799.

Human Pathology
|January 29, 2015
PubMed

Insights

Decreased expression of ARID1A protein in clear cell renal cell carcinoma (CCRCC) correlates with higher tumor grade and advanced stage. Low ARID1A expression is linked to poorer survival, suggesting its potential as a prognostic marker for CCRCC patients.

Area of Science:

  • Oncology
  • Molecular Pathology
  • Cancer Genetics

Background:

  • Clear cell renal cell carcinoma (CCRCC) is the most prevalent kidney cancer subtype, often presenting with a poor prognosis.
  • Genetic alterations in VHL, PBRM1, and ARID1A are frequently observed in CCRCC.
  • ARID1A protein expression is implicated in tumor progression and prognosis across various cancers.

Purpose of the Study:

  • To investigate the nuclear expression levels of ARID1A in CCRCC tissues.
  • To correlate ARID1A expression with clinicopathological features of CCRCC.
  • To evaluate the association between ARID1A expression and patient prognosis in CCRCC.

Main Methods:

  • Immunohistochemistry was employed to assess nuclear ARID1A expression in 290 CCRCC cases.
  • Cases were stratified into low- and high-ARID1A expression groups based on nuclear staining intensity.
  • Statistical analyses, including Cox regression, were performed to determine prognostic significance.

Main Results:

  • Reduced nuclear ARID1A expression was significantly associated with higher tumor nuclear grade and advanced pTNM stage (P < .001 and P = .013, respectively).
  • Patients with low ARID1A expression exhibited significantly shorter cancer-specific and progression-free survival times (P = .001 and P < .001, respectively).
  • ARID1A expression emerged as an independent prognostic factor for progression-free survival (P = .009).

Conclusions:

  • Nuclear ARID1A expression is significantly linked to adverse clinicopathological features in CCRCC.
  • Decreased ARID1A expression serves as a potential indicator of poor prognosis in CCRCC patients.
  • ARID1A may represent a novel and valuable prognostic biomarker for clear cell renal cell carcinoma.
Keywords:
ARID1AClear cell renal cell carcinomaImmunohistochemistryPrognosisProgression

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