Related Experiment Video
Updated: Apr 18, 2026
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
11.8K
Multistep tumorigenesis in peripheral T cell lymphoma
1Department of Hematology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. sakatama-tky@umin.net.
International Journal of Hematology
|January 29, 2015
Summary
Premalignant cells in peripheral T cell lymphomas (PTCL) may originate from immature hematopoietic cells. Mutations in TET2 and RHOA drive the evolution of these cells into PTCL.
Area of Science:
- Hematology
- Oncology
- Molecular Biology
Background:
- Peripheral T cell lymphomas (PTCL) are typically classified as mature T cell neoplasms.
- Emerging evidence suggests premalignant cells may arise during immature hematopoietic differentiation before evolving into PTCL.
- Acquisition of Ten-Eleven Translocation 2 (TET2) mutations is implicated in the establishment of these premalignant cells.
Purpose of the Study:
- To investigate the role of specific mutations in the pathogenesis of PTCL.
- To explore the relationship between premalignant TET2 mutations and tumor-specific RHOA mutations in PTCL.
- To understand the multistep process of tumorigenesis in PTCL development.
Main Methods:
- Analysis of genetic mutations in PTCL samples.
- Investigating the co-occurrence of TET2 and RHOA mutations.
- Studying the clonal evolution pathways in PTCL.
Main Results:
- Premalignant cells in PTCL may originate from immature hematopoietic precursors.
- Acquisition of TET2 mutations appears crucial for establishing premalignant cells.
- In PTCL with follicular helper T cell features, tumor-specific G17V RHOA mutations frequently co-occur with premalignant TET2 mutations.
- The G17V RHOA mutation may drive clonal evolution from premalignant to malignant cells.
Conclusions:
- PTCL pathogenesis likely involves a multistep tumorigenesis process.
- TET2 and RHOA mutations play significant roles in the development and evolution of PTCL.
- Premalignant lesions are critical in the progression to mature T cell lymphomas.
Related Concept Videos
02:07Tumor Progression
8.0K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
8.0K
02:21Cancers Originate from Somatic Mutations in a Single Cell
15.8K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
15.8K