Aerobic Training Activates Interleukin 10 for Colon Anticarcinogenic Effects

Area of Science:

• Oncology
• Exercise Physiology
• Immunology

Background:

• Physical exercise is recognized for its protective effects against colon carcinogenesis.
• Different exercise modalities may yield distinct physiological outcomes.
• The specific impact of aerobic versus resistance training on early colon cancer development requires clarification.

Purpose of the Study:

• To investigate whether aerobic and resistance training differentially influence the development of early carcinogenic events in the colon.
• To elucidate the role of interleukin-10 (IL-10) in mediating the effects of exercise on colon carcinogenesis.

Main Methods:

• Male BALB/c, C57/BL6, and IL-10 knockout mice were exposed to a colon carcinogen.
• BALB/c mice underwent aerobic (swimming) or resistance (ladder climbing with load) training.
• C57/BL6 and IL-10 mice were subjected to aerobic training (swimming).

Main Results:

• Both aerobic and resistance training reduced markers of cellular damage and oxidative stress.
• Aerobic exercise alone increased serum glutathione levels and significantly reduced colon preneoplastic lesions by 36%.
• Aerobic training upregulated colonic IL-10 expression and reduced cyclooxygenase-2 expression, effects abrogated in IL-10 knockout mice.

Conclusions:

• Interleukin-10 (IL-10) plays a critical role in mediating the antipreneoplastic effects of aerobic exercise in the colon.
• Aerobic exercise demonstrates significant potential in preventing early colon cancer development, mediated by IL-10.