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Changes in chronotype after stroke: a pilot study.

Thomas Kantermann1, Andreas Meisel2, Katharina Fitzthum2

  • 1Chronobiology Unit, Groningen Institute for Evolutionary Life Sciences, University of Groningen , Groningen , The Netherlands ; Clinical Centre, Institute for Occupational, Social and Environmental Medicine, Ludwig-Maximilians University Munich , Munich , Germany.

Frontiers in Neurology
|January 29, 2015
PubMed
Summary
This summary is machine-generated.

Stroke can alter your body clock, especially in severe cases. The timing of stroke relative to your internal body clock influences how your chronotype shifts post-stroke.

Keywords:
NIHSSchronotypeinternal timemRSsleepstrokestroke location

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Area of Science:

  • Neurology
  • Chronobiology
  • Sleep Medicine

Background:

  • Stroke is a leading cause of disability.
  • Chronotype, or an individual's internal body clock, influences physiological processes.
  • The relationship between stroke timing, severity, and chronotype shifts is not well understood.

Purpose of the Study:

  • To investigate the association between stroke onset and severity with chronotype.
  • To explore the concept of internal time of stroke (InTstroke) and its impact.
  • To determine if stroke influences chronotype (MSFsc) and how this relates to stroke characteristics.

Main Methods:

  • A cross-sectional study involving 56 first-ever ischemic stroke patients.
  • Chronotype assessed using the Munich ChronoType Questionnaire (MCTQ) before and after stroke.
  • Stroke severity evaluated using the National Institute of Health Stroke Scale (NIHSS) and modified Ranking Scale (mRS).

Main Results:

  • Most strokes occurred between noon and midnight.
  • No significant association was found between chronotype (MSFsc) and stroke onset time.
  • Chronotype (MSFsc) significantly changed post-stroke, particularly in patients with more severe strokes.
  • Changes in MSFsc were influenced by the internal time of stroke (InTstroke).
  • Evidence suggests stroke location may also affect chronotype changes.

Conclusions:

  • Stroke can significantly alter an individual's chronotype, with changes more pronounced in severe cases.
  • The timing of stroke relative to the internal body clock plays a role in post-stroke chronotype shifts.
  • Further research with larger trials is warranted to confirm these findings and explore clinical implications.