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Low-density-lipoprotein particle size predicts a poor outcome in patients with atherothrombotic stroke

Tae-Jin Song1, Hyun-Ji Cho2, Yoonkyung Chang3

  • 1Department of Neurology, Ewha Womans University School of Medicine, Seoul, Korea. ; Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.

Journal of Clinical Neurology (Seoul, Korea)
|January 29, 2015
PubMed

Insights

Small low-density lipoprotein (LDL) particles are linked to worse outcomes in atherothrombotic stroke patients. Measuring LDL particle size may help predict stroke severity and functional recovery.

Area of Science:

  • Cardiovascular Research
  • Neurology
  • Lipid Metabolism

Background:

  • Low-density lipoprotein (LDL) particle size is a significant cardiovascular risk factor.
  • Small LDL particles are associated with atherogenic potential.

Purpose of the Study:

  • To investigate the association between LDL particle size and stroke severity.
  • To determine if LDL particle size correlates with functional outcomes in atherothrombotic stroke patients.

Main Methods:

  • Prospective enrollment of 248 patients with first-episode cerebral infarction.
  • LDL particle size measured using nondenaturing polyacrylamide gradient gel electrophoresis.
  • Stroke severity assessed by NIHSS; functional outcome by mRS at 3 months.

Main Results:

  • LDL particle size was inversely correlated with cerebral artery stenosis.
  • Smaller LDL particle size independently predicted increased stroke severity (NIHSS score ≥5).
  • Smaller LDL particle size independently predicted poor functional outcome (mRS score ≥3).

Conclusions:

  • Small LDL particles are independently associated with poorer stroke outcomes.
  • LDL particle size serves as a potential prognostic biomarker for atherothrombotic stroke.
Abstract

Keywords:
atherosclerosislipoproteinlow-density-lipoprotein particle sizestroke outcomestroke severity

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