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Predictors of renal replacement therapy and mortality in children with chronic kidney disease

Jameela A Kari1, Sherif M El Desoky, Youssef M Farag

  • 1Department of Pediatrics, King Abdulaziz University Hospital, PO Box 80215, Jeddah 21589, Kingdom of Saudi Arabia. Fax. +966 (12) 6684603. E-mail. jkari@doctors.org.uk.

Saudi Medical Journal
|January 29, 2015
PubMed

Insights

Congenital causes are the main driver of pediatric chronic kidney disease (CKD) in western Saudi Arabia. Hypertension is a significant risk factor for both renal replacement therapy (RRT) and mortality in children with CKD.

Area of Science:

  • Pediatric Nephrology
  • Epidemiology
  • Renal Medicine

Background:

  • Chronic kidney disease (CKD) in children poses a significant health challenge globally.
  • Understanding the epidemiology and risk factors for CKD progression in pediatric populations is crucial for effective management.
  • Congenital anomalies are a leading cause of CKD in children, necessitating focused research.

Purpose of the Study:

  • To investigate the epidemiological characteristics of pediatric chronic kidney disease (CKD).
  • To identify risk factors associated with the need for renal replacement therapy (RRT) and mortality in children with CKD.
  • To compare outcomes between children with congenital versus non-congenital causes of CKD.

Main Methods:

  • A retrospective cohort study was conducted involving 1,000 children diagnosed with CKD between 2006 and 2014.
  • Data on consanguinity, hypertension, nationality, and etiology of CKD were analyzed.
  • Statistical analysis was performed to determine risk factors for RRT and mortality.

Main Results:

  • Congenital causes accounted for the majority of pediatric CKD cases (53.7%).
  • Children with congenital CKD presented younger, had more advanced disease, higher consanguinity rates, and required RRT more often.
  • Hypertension was a significant risk factor for both RRT (RR=5.29) and mortality (RR=2.46); Saudi nationality was also linked to RRT (RR=1.49).

Conclusions:

  • Congenital etiologies are the primary cause of pediatric CKD in western Saudi Arabia.
  • Hypertension is a critical predictor of both RRT and mortality in children with CKD.
  • Early identification and management of hypertension are essential for improving outcomes in pediatric CKD patients.
Abstract

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