Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inertia-Driven Mitral and Aortic Valves: The Isovolumic Myth.

Medical research archives·2025
Same author

A numerical framework for preprocedural prosthetic valve positioning and hemodynamic evaluation.

Biomechanics and modeling in mechanobiology·2025
Same author

4D flow MRI enhances prototype testing of a total artificial heart.

Scientific reports·2025
Same author

Virtual left atrial appendage occlusion in paroxysmal atrial fibrillation during sinus rhythm predicts variable reductions in blood stasis.

The Journal of physiology·2025
Same author

Observer- and sequence variability in personalized 4D flow MRI-based cardiovascular models.

Scientific reports·2025
Same author

Haemodynamic significance of extrinsic outflow graft stenoses during HeartMate 3™ therapy.

European heart journal. Imaging methods and practice·2024

Related Experiment Video

Updated: Apr 18, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

4.7K

Is aortic wall shear stress affected by aging? An image-based numerical study with two age groups.

Jonas Lantz1, Johan Renner2, Toste Länne3

  • 1Department of Science and Technology, Linköping University, SE-581 83 Linköping, Sweden; Swedish e-Science Research Centre (SeRC), Stockholm, Sweden.

Medical Engineering & Physics
|January 30, 2015
PubMed
Summary

Arterial size increases with age, impacting blood flow. Older males showed decreased time-averaged wall shear stress in the aorta, likely due to larger diameters and reduced stroke volume, while the oscillatory shear index remained unchanged.

Keywords:
AgingAortaComputational fluid dynamicsMagnetic resonance imagingOscillatory shear indexWall shear stress

More Related Videos

Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery
06:18

Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery

Published on: December 6, 2024

1.2K
Multimodal Study of Murine Cardiovascular Remodeling: Four-Dimensional Ultrasound and Mass Spectrometry Imaging
09:43

Multimodal Study of Murine Cardiovascular Remodeling: Four-Dimensional Ultrasound and Mass Spectrometry Imaging

Published on: January 10, 2025

2.0K

Related Experiment Videos

Last Updated: Apr 18, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

4.7K
Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery
06:18

Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery

Published on: December 6, 2024

1.2K
Multimodal Study of Murine Cardiovascular Remodeling: Four-Dimensional Ultrasound and Mass Spectrometry Imaging
09:43

Multimodal Study of Murine Cardiovascular Remodeling: Four-Dimensional Ultrasound and Mass Spectrometry Imaging

Published on: January 10, 2025

2.0K

Area of Science:

  • Cardiovascular physiology
  • Biomedical engineering
  • Gerontology

Background:

  • Arterial size naturally increases throughout life.
  • The effects of age-related arterial size changes on blood flow dynamics are not well understood.

Purpose of the Study:

  • To compare the aortic blood flow field between young and older males.
  • To investigate the relationship between aging, aortic geometry, and wall shear stress.

Main Methods:

  • Magnetic resonance imaging (MRI) was used to obtain aortic geometries.
  • Computational fluid dynamics (CFD) was employed to compute the blood flow field.
  • Wall shear stress (WSS) and oscillatory shear index (OSI) were derived from CFD simulations.

Main Results:

  • Time-averaged wall shear stress (TAWSS) was found to decrease with increasing age.
  • This decrease in TAWSS is likely attributed to increased aortic diameter and decreased stroke volume in older individuals.
  • The oscillatory shear index (OSI) showed no significant difference between the young and older male groups.

Conclusions:

  • Aging leads to reduced time-averaged wall shear stress in the aorta, potentially impacting vascular health.
  • Aortic geometry and stroke volume changes associated with aging are key factors influencing WSS.
  • Aging does not appear to alter the oscillatory nature of wall shear stress in the aorta.