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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
6.1K
Stem Cell Niche01:26

Stem Cell Niche

6.7K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Related Experiment Video

Updated: Apr 18, 2026

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma
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Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

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Melanoma stem cells.

Alexander Roesch1

  • 1Department of Dermatology, Venereology, and Allergology, University Hospital Essen, Germany.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|January 30, 2015
PubMed
Summary

Cancer stem cells are key to melanoma biology, but identifying them is challenging. Targeting these cells may improve melanoma treatments and overcome resistance.

Area of Science:

  • Melanoma Biology
  • Cancer Stem Cell Research
  • Tumor Microenvironment Dynamics

Background:

  • The cancer stem cell (CSC) concept offers new insights into melanoma biology.
  • Understanding CSCs requires integrating genetic evolution and tumor microenvironment variability.
  • Current challenges in CSC identification and biomarker discovery hinder clinical translation.

Purpose of the Study:

  • To explore the role of cancer stem cells in melanoma.
  • To discuss the implications of CSC complexity for therapeutic strategies.
  • To highlight how methodological challenges offer new perspectives on melanoma plasticity.

Main Methods:

  • Review of current understanding of cancer stem cell biology in melanoma.
  • Analysis of the interplay between genetic evolution, cell phenotype, and tumor microenvironment.

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Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
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  • Discussion of methodological limitations in CSC research.

    • Main Results:

    • The CSC concept is crucial but must be part of a holistic cancer model.
    • Methodological difficulties in CSC identification reveal melanoma's phenotypic heterogeneity and plasticity.
    • Targeting CSC subpopulations shows promise for overcoming treatment resistance.

    Conclusions:

    • Cancer stem cells are integral to melanoma, requiring a comprehensive model.
    • Melanoma's phenotypic plasticity, highlighted by CSC research challenges, impacts future therapies.
    • Combination therapies targeting CSCs could enhance treatment efficacy and overcome resistance.