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Effects of curcumin on antioxidation in diabetic rats
Mingsan Miao1, Lin Guo1, Shuo Tian1
1Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, china.
Abstract:
To investigate the effects of curcumin on antioxidation and its mechanism in diabetic rat model.After streptozotocin (STZ) induced diabetic rat model, large, medium and small doses of curcumin group were partly given curcumin solution 200,100,50mg•kg-1, administered once a day, continuously 30 days. In 30th day, determine blood glucose (BG) value, after the last injection, determine the serum superoxide dismutase (SOD), malondialdehyde (MDA), glycosylated serum protein (GSP) and free fatty acid (FFA) levels. Compared with the model group rats, In the 10th, 30th administrate, each dose of curcumin group rats' BG, MDA, GSP, FFA levels were significantly reduced, SOD levels was increased significantly.curcumin can significantly improve the antioxidant capacity of diabetic model, improve the metabolic disorder.
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