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Efficacy of contemporary and novel Intracanal medicaments against enterococcus faecalis

R F Marickar1, R V Geetha2, P Neelakantan1

  • 1Saveetha Dental College and Hospitals, Saveetha University, Chennai, India.

The Journal of Clinical Pediatric Dentistry
|January 30, 2015
PubMed
Abstract

Insights

Propolis, curcumin, chlorhexidine gel (CHX), and metronidazole gel (MZ) effectively reduced Enterococcus faecalis in vitro. All agents, except calcium hydroxide, showed time-dependent antibacterial effects.

Area of Science:

  • Endodontics
  • Microbiology
  • Dental Materials

Background:

  • Enterococcus faecalis is a common bacterium found in root canal infections.
  • Effective intracanal medicaments are crucial for successful endodontic treatment.
  • Investigating natural compounds like propolis and curcumin alongside conventional agents is important.

Purpose of the Study:

  • To compare the in vitro antibacterial activity of propolis, curcumin, chlorhexidine gel (CHX), and metronidazole gel (MZ) against Enterococcus faecalis.
  • To evaluate the time-dependent bactericidal effect of these agents.
  • To assess calcium hydroxide as a control.

Main Methods:

  • Agar diffusion and tube dilution tests were used to determine the inhibitory effect of medicaments.
  • Time-kill assays evaluated the rate of bactericidal activity.
  • Statistical analysis included ANOVA and post hoc Tukey tests.

Main Results:

  • Chlorhexidine gel (CHX) exhibited the largest zone of inhibition, comparable to curcumin and metronidazole gel (MZ).
  • Calcium hydroxide showed only contact inhibition.
  • Time-kill assays confirmed a time-dependent antibacterial action for all tested agents except calcium hydroxide.

Conclusions:

  • Propolis, curcumin, CHX, and MZ demonstrated significant antibacterial activity against E. faecalis in vitro.
  • All tested intracanal medicaments, excluding calcium hydroxide, exhibited a time-dependent reduction in viable bacteria.
  • These findings support the potential of propolis and curcumin as alternatives or adjuncts in endodontic treatment.
Keywords:
Calcium hydroxideChlorhexidineCurcuminIntracanal medicamentMetronidazolePropolisRoot canal failure

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