Related Experiment Video

Updated: Apr 18, 2026

Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents
10:53

Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents

Published on: July 3, 2013

21.2K

Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia.

Sakima A Smith1, Amy C Sturm1, Jerry Curran1

  • 1From Dorothy M. Davis Heart and Lung Research Institute (S.A.S., A.C.S., J.C., C.F.K., S.C.L., I.M.B., V.P.L., M.M., I.P., L.D.H., T.R.W., P.W., R.W., P.F.B., P.M.J., A.K., R.S.H., M.S., J.M., C.A.C., T.J.H., P.J.M.), Department of Internal Medicine, Division of Cardiovascular Medicine (S.A.S., R.W., P.F.B., P.J.M.), Department of Internal Medicine, Division of Human Genetics (A.C.S., P.M.J.), Department of Physiology and Cell Biology (J.C., C.F.K., S.C.L., M.M., I.P., L.D.H., T.R.W., P.W., P.M.J., P.J.M.), and Department of Surgery (A.K., R.S.H., M.S., J.M.), The Ohio State University Wexner Medical Center; Columbus; College of Pharmacy (I.M.B., V.P.L., C.A.C.) and Department of Biomedical Engineering, College of Engineering (T.J.H.), The Ohio State University, Columbus; Division of Life Science and Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay Kowloon, Hong Kong (Z.W., M.Z.); Department of Biology, South University of Science and Technology of China, Shenzhen, Guangdong, China (Z.W.); Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany (N.V., D.D.); Krannert Institute of Cardiology and Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis (D.B., K.G.S., M.V.); and Department of Neuroscience, Baylor College of Medicine; Houston, TX (C.Z., M.N.R.).

Circulation
|January 30, 2015
PubMed
Summary

Beta-II spectrin is crucial for heart electrical activity and protein localization. Mutations disrupt this, causing severe arrhythmias and heart failure, highlighting its role in cardiac health.

Keywords:
arrhythmias, cardiaccatecholaminergic polymorphic ventricular arrhythmiacytoskeletonion channelsprotein transportventricular tachycardia

More Related Videos

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

1.9K
Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes11:33

Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes

Published on: March 12, 2013

13.8K

Related Concept Videos

Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
2.7K
Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
5.4K
Dysrhythmias I: Introduction01:15

Dysrhythmias I: Introduction

Dysrhythmias refers to abnormalities in the heart's rhythm. They result from disruptions in the heart's electrical conduction system, which includes the sinoatrial(SA)node, atrioventricular(AV) node, the bundle of His, bundle branches, and Purkinje fibers.Definition and PathophysiologyDysrhythmias result from disorders of impulse formation, impulse conduction, or both. The heart contains specialized cells in the sinoatrial node, atrioventricular node, and the bundle of His and Purkinje fibers...
801
Dysrhythmias IV: Characteristics of Bradyarrhythmias01:18

Dysrhythmias IV: Characteristics of Bradyarrhythmias

Bradyarrhythmias are cardiac rhythm disorders characterized by a slower-than-normal heart rate, typically defined as fewer than 60 beats per minute. Some of which are discussed here:Sinus BradycardiaSinus bradycardia presents a heart rate lower than 60 beats per minute, with a regular rhythm originating from the SA node. The ECG typically shows normal P waves preceding each QRS complex, a normal PR interval (0.12 to 0.20 seconds), and a normal QRS duration (0.06 to 0.10 seconds).First-Degree AV...
845
Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
10.6K
Dysrhythmias V: Evaluating Dysrhythmias01:30

Dysrhythmias V: Evaluating Dysrhythmias

Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...
488