Related Experiment Video
Updated: Apr 18, 2026
08:45
New Thrombectomy Technique for Total Portal Vein Thrombosis in Liver Transplantation
Published on: June 27, 2025
2.0K
Colectomy is a risk factor for venous thromboembolism in ulcerative colitis
Gilaad G Kaplan1, Allen Lim1, Cynthia H Seow1
1Gilaad G Kaplan, Allen Lim, Cynthia H Seow, Gordon W Moran, Subrata Ghosh, Yvette Leung, James Hubbard, Remo Panaccione, Inflammatory Bowel Disease Clinic, University of Calgary, Calgary AB T2N 4N1, Canada.
World Journal of Gastroenterology
|January 30, 2015
Summary
Venous thromboembolism (VTE) is more common in ulcerative colitis (UC) patients undergoing colectomy compared to those responding to medical therapy. Prophylaxis may be insufficient in colectomy patients.
Area of Science:
- Gastroenterology
- Vascular Surgery
- Epidemiology
Background:
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
- Venous thromboembolism (VTE) is a known complication in patients with inflammatory conditions.
- The risk of VTE in UC patients undergoing colectomy versus medical management requires further investigation.
Purpose of the Study:
- To compare the incidence of VTE in hospitalized ulcerative colitis (UC) patients who respond to medical management versus those requiring colectomy.
- To identify risk factors associated with VTE in UC patients.
Main Methods:
- Population-based surveillance data from 1997-2009 was analyzed.
- Adult UC patients were stratified into three groups: responsive to medical therapy, medically refractory requiring emergent colectomy, and elective colectomy.
- Logistic regression was used to determine the effect of disease course on VTE, adjusting for confounders.
Main Results:
- VTE prevalence was 1.3% in medically responsive UC patients, 8.7% in emergent colectomy patients, and 4.9% in elective colectomy patients.
- Elective and emergent colectomy were significant risk factors for VTE (adjusted OR=3.69 and 5.28, respectively).
- Intra-abdominal VTE was most common (45.8%), and 16.7% of VTE cases were diagnosed post-discharge.
Conclusions:
- Colectomy, especially in medically refractory UC patients, is associated with an increased risk of VTE.
- Current VTE prophylaxis strategies may be insufficient for patients undergoing colectomy for UC.
Related Concept Videos
01:30Venous Thrombosis I: Introduction
750
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
750
01:29Venous Thrombosis III: Interprofessional Care
473
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
473
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
447
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
447
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
1.6K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.6K
01:21Inflammatory Bowel Disease V: Surgical Management
905
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
905
01:30Venous Thrombosis IV: Nursing Management
398
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
398