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Drug therapy for hypertension in the elderly
1Department of Family and Community Medicine, College of Pharmacy, University of Arizona, Tucson 85721.
The Journal of Family Practice
|January 1, 1989
Summary
Angiotensin-converting enzyme (ACE) inhibitors offer effective hypertension treatment for seniors, matching traditional methods without adverse effects. Combining ACE inhibitors with diuretics improves outcomes and maintains quality of life.
Area of Science:
- Gerontology
- Cardiovascular Medicine
- Pharmacology
Background:
- Essential hypertension is a significant health concern in the elderly, increasing morbidity and mortality.
- Traditional stepped-care therapy (diuretics, sympatholytics, beta-blockers) is effective in 50-60% but causes adverse effects and reduces quality of life.
Purpose of the Study:
- To evaluate angiotensin-converting enzyme (ACE) inhibitors as an alternative antihypertensive therapy for elderly patients.
- To compare the efficacy and side effect profile of ACE inhibitors versus traditional therapies.
Main Methods:
- Review of controlled trials comparing ACE inhibitors with traditional stepped-care approaches.
- Analysis of adverse effects, including sexual dysfunction, CNS impairment, and quality of life measures.
Main Results:
- ACE inhibitors demonstrate comparable efficacy to traditional therapies without associated adverse effects.
- Combination therapy with an ACE inhibitor and a diuretic is effective in up to 85% of patients.
- ACE inhibitors maintain patient quality of life and may benefit those with heart failure.
Conclusions:
- ACE inhibitors, alone or with diuretics, represent a valuable alternative to traditional antihypertensive treatments in the elderly.
- This approach effectively manages hypertension while minimizing adverse effects and preserving quality of life.