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[Effect of Shexiang Baoxin pill on coronary vasodilation by analysis of coronary angiography]

Xian-Zhao Zhang, Ya-Min Hou, Zhi-Hong Ou

    Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine
    |January 31, 2015
    PubMed

    Insights

    Shexiang Baoxin Pill (SBP) effectively dilates coronary arteries in patients with normal or stenotic coronary angiography (CAG) findings. This traditional Chinese medicine treatment does not significantly affect heart rate or blood pressure.

    Area of Science:

    • Cardiology
    • Pharmacology
    • Traditional Chinese Medicine

    Background:

    • Coronary artery disease (CAD) remains a leading cause of mortality worldwide.
    • Vasodilation is a critical factor in improving coronary blood flow.
    • Shexiang Baoxin Pill (SBP) is a traditional Chinese medicine used for cardiovascular conditions.

    Purpose of the Study:

    • To investigate the effect of Shexiang Baoxin Pill (SBP) on coronary vasodilation.
    • To analyze changes in coronary artery diameter using coronary angiography (CAG).

    Main Methods:

    • A randomized controlled trial involving 300 patients undergoing CAG.
    • Patients received either SBP or placebo sublingually before CAG.
    • Quantitative angiography analysis measured coronary artery diameters before and after administration.

    Main Results:

    • SBP significantly increased coronary artery diameter in both normal and stenotic arteries (P < 0.01).
    • No significant changes in heart rate, systolic, or diastolic blood pressure were observed.
    • SBP demonstrated superior vasodilation compared to placebo (P < 0.05, P < 0.01).

    Conclusions:

    • Shexiang Baoxin Pill (SBP) effectively induces coronary vasodilation.
    • SBP is safe for cardiovascular function, showing no adverse effects on heart rate or blood pressure.
    • SBP shows potential as a therapeutic agent for improving coronary blood flow.
    Abstract

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