Related Experiment Video
Updated: Apr 18, 2026
06:13
Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
Published on: December 1, 2023
2.0K
Endocrine response to acute resistance exercise in obese versus lean physically active men
Daniela A Rubin1, Hoang N Pham, Eric S Adams
1Department of Kinesiology, California State University, 800 N. State College Blvd., Fullerton, CA, 92834, USA, drubin@fullerton.edu.
European Journal of Applied Physiology
|January 31, 2015
Summary
Physically active obese men show similar immediate growth hormone and testosterone responses to resistance exercise compared to lean men. However, integrated hormone concentrations during recovery are lower in obese individuals.
Area of Science:
- Endocrinology
- Exercise Physiology
- Obesity Research
Background:
- Resistance exercise (RE) stimulates crucial endocrine responses impacting body composition and metabolism.
- Excess adiposity can negatively influence hormonal adaptations to exercise in sedentary individuals.
Purpose of the Study:
- To compare the resistance exercise-associated endocrine responses (growth hormone [GH], insulin-like growth factor-1 [IGF-1], and testosterone) in lean versus obese physically active men.
- To investigate the impact of excess adiposity on hormonal profiles during and after a muscular endurance resistance exercise protocol.
Main Methods:
- Ten healthy, physically active obese males and ten lean counterparts underwent a standardized muscular endurance resistance exercise protocol.
- Blood samples were collected pre-exercise, immediately post-exercise (IP), and at three time points during a one-hour recovery period.
- Hormonal concentrations (GH, IGF-1, testosterone) were analyzed, comparing responses between the lean and obese groups.
Main Results:
- No significant group-by-time interactions were observed for growth hormone (GH) or luteinizing hormone (LH).
- A trend suggested higher immediate post-exercise insulin-like growth factor-1 (IGF-1) in lean individuals compared to obese.
- Testosterone levels were similar immediately post-exercise but lower in obese individuals at 30 minutes into recovery. Area Under the Curve (AUC) for all hormones was lower in obese individuals.
Conclusions:
- Excess adiposity does not appear to impair immediate GH and testosterone responses to resistance exercise in active males.
- Obesity may negatively impact IGF-1 responses and overall integrated hormonal concentrations during recovery.
- These findings highlight potential differences in endocrine adaptation to exercise based on body composition in active populations.
More Related Videos
06:28A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
Published on: April 28, 2023
1.5K
07:26Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
Published on: October 17, 2018
21.7K
Related Concept Videos
01:27Exercise and Muscle Performance
6.4K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
6.4K
01:20Exercise and Cardiovascular Response
6.4K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
6.4K
01:20Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
309
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
309
01:21Drug Dosing: Obese Patients
350
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
350
01:26Cellular Adaptation II: Hypertrophy
5
Hypertrophy is the increase in the size of individual cells, resulting in the enlargement of a tissue or organ. Unlike hyperplasia, which involves an increase in cell number, hypertrophy is characterized by an increase in cell volume. This process often occurs in response to higher functional demand or hormonal stimulation, leading to the production of more structural proteins and organelles, thereby enhancing the cells' work capacity.There are two primary types of hypertrophy:...
5
01:25Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
423
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
423