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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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T Cell Activation and Clonal Selection01:22

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cell-mediated Immune Responses01:40

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Related Experiment Video

Updated: Apr 18, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

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Interleukin-27 in T cell immunity.

Yukiko Iwasaki1, Keishi Fujio2, Tomohisa Okamura3

  • 1Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. yunyan-todai@umin.ac.jp.

International Journal of Molecular Sciences
|January 31, 2015
PubMed
Summary

Interleukin 27 (IL-27) is a cytokine that modulates immune responses by affecting various immune cells, particularly T cells. It can both enhance and limit immune activity, showing therapeutic potential for diseases.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Interleukin 27 (IL-27) is a cytokine belonging to the IL-12/IL-23 family.
  • IL-27 exhibits diverse functions, capable of both augmenting and suppressing immune responses.
  • It interacts with multiple cell types, including T cells, B cells, macrophages, dendritic cells, and NK cells.

Purpose of the Study:

  • To provide an overview of Interleukin 27 (IL-27) biology.
  • To elucidate the mechanisms of IL-27 action on different T cell subsets.
  • To describe the structure and production of IL-27.

Main Methods:

  • Review of existing literature on IL-27.
  • Analysis of signaling pathways involved in IL-27 function, including STAT1 and STAT3.
  • Examination of IL-27's impact on T cell differentiation and cytokine production.

Main Results:

  • IL-27 induces T helper 1 (Th1) cell expansion via STAT1-T-bet signaling.
  • IL-27 inhibits T helper 17 (Th17) cell development and promotes IL-10 production in a STAT1/STAT3-dependent manner.
  • Different T cell subsets exhibit unique responses to IL-27.

Conclusions:

  • IL-27 plays a complex role in regulating immune responses, with distinct effects on various T cell subsets.
  • Understanding IL-27's biology is crucial for its therapeutic applications.
  • IL-27 holds promise for treating various human diseases due to its immunomodulatory properties.