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Updated: Apr 18, 2026
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The Use of Thermal Infra-Red Imaging to Detect Delayed Onset Muscle Soreness
Published on: January 22, 2012
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Delayed-onset muscle soreness: a pilot study to assess analgesic study design features
Neil Singla1, Paul J Desjardins, Evelyn B Cosca
1Department of Anesthesia, Lotus Clinical Research, Huntington Hospital, Pasadena, CA, USA, Department of Diagnostic Sciences, Rutgers School of Dental Medicine, Newark, NJ, USA.
Pain
|January 31, 2015
Summary
Topical diclofenac sodium gel 1% effectively reduced pain from delayed-onset muscle soreness (DOMS) compared to placebo. This study followed best practices for analgesic research in the DOMS model.
Area of Science:
- Exercise Physiology
- Pain Research
- Pharmacology
Background:
- Delayed-onset muscle soreness (DOMS) research often lacks adherence to acute pain study design standards.
- Established analgesic study designs can improve assay sensitivity in DOMS models.
Purpose of the Study:
- To assess the efficacy of topical diclofenac sodium 1% versus placebo for DOMS pain.
- To implement rigorous study design standards in a DOMS analgesic investigation.
Main Methods:
- Randomized, double-blind, placebo-controlled, within-subject design.
- Topical diclofenac sodium gel 1% applied every 6 hours for 48 hours to one leg, placebo to the other.
- Pain intensity assessed at rest, standing, and walking.
Main Results:
- Diclofenac sodium gel 1% significantly reduced walking pain intensity at 24 hours (SPID 24 = 34.9) compared to placebo (SPID 24 = 23.6; P = 0.032).
- The study design demonstrated reasonable assay sensitivity.
Conclusions:
- Topical diclofenac sodium gel 1% is effective for managing DOMS pain.
- Adherence to analgesic research best practices enhances DOMS study validity and assay sensitivity.
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